Tuesday 15 November 2016

Nicotine Withdrawal: Symptoms

Nicotine Withdrawal: Symptoms

  •     Headache
  •     Nausea
  •     Constipation or diarrhea
  •     Fatigue, drowsiness, and insomnia
  •     Irritability
  •     Difficulty concentrating
  •     Anxiety
  •     Depressed mood
  •     Increased hunger and caloric intake
  •     Increased desire for the taste of sweets
  •     Tobacco cravings

Thursday 27 October 2016

PCSK9 inhibitors are monoclonal antibodies (MABs

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome

It is ubiquitously expressed in many tissues and cell types.PCSK9 binds to the receptor for low-density lipoprotein (LDL) cholesterol (LDL-C). In the liver, the LDL receptor (LDLR) removes LDL-C from the blood. When PCSK9 binds to the LDLR, the receptor is broken down and can no longer remove LDL-C from the blood. If PCSK9 is blocked, more LDLRs will be present on the surface of the liver and will remove more LDL-C from the blood.Therefore, blocking PCSK9 can lower blood cholesterol levels. Similar genes (orthologs) are found across many species. PCSK9 is inactive when first synthesized, because a section of peptide chains blocks their activity; proprotein convertases remove that section to activate the enzyme.